Solomon Segal, M.D.
Solomon Segal, M.D.Universidade Federal do Rio Grande do Sul in Porto Alegre, Brazil
Education and Previous Work
I earned my medical degree (M.D.) from Universidade Federal do Rio Grande do Sul in Porto Alegre, Brazil and received residency training in Neurosurgery in the University of Ljubljana, Slovenia and at Homolka's Hospital in Prague, Czech Republic. I came to the U.S.A. in 1993 and undertook a fellowship in Microsurgical Anatomy at the Practical Anatomy and Surgical Technique Workshop of Saint Louis. Although my training was in the area of Medicine and Neurosurgery, I became increasingly involved with the teaching of neuroanatomy by first working and then leading the program in Continuing Medical Education at the Practical Anatomy Workshop of Saint Louis. Subsequently, I have taught neuroanatomy at the Mount Sinai School of Medicine, City University of New York, New York University and Columbia University in the City of New York. At New York University Department of Psychiatry I was introduced to a dedicated research environment as I utilized my neuroanatomical skills to train postdoctoral fellows as well as to conduct structural and functional neuroimaging studies, which tested hypotheses on the process of aging of the brain and dementia. From 2002 to 2005 I received additional training in functional neuroimaging at the Positron Emission Tomography Facility, Brookhaven National Laboratory, Department of Energy, U.S.A. As I became interested in pursuing my career as an independent neuroscientist, I undertook (2005 - 2009) two additional postdoctoral fellowships in Geriatric Neuropsychiatry Research and Translational Neuroscience at the Department of Psychiatry at Columbia University and New York State Psychiatric Institute.
My primary teaching serves a diverse population of students, including medical students and allied health professions students who take anatomy courses as a requirement for their training. Additional students are from the CAPS program as well as graduate students at the MS and PhD levels. I lecture and supervise laboratory activities in several courses (see below). I also lecture to medical residents in the specialties of neurology and ENT.
Gross Anatomy in Human Anatomy Module
Neuroanatomy in Nervous System Module
ANAT500 - Human Gross Anatomy
ANAT510 - Human Histology and Ultrastructure (Course Associate Director)
ANAT530 - Human Systems Neurobiology
ANAT550 - Advanced Dissections in Human Anatomy
ANAT580 - Human Anatomy Independent Study
ANAT630 - Advanced Systems Neurobiology
ANAT400 - Gross Anatomy for Allied Health Professions
A - 403 - Advanced Topics in Anatomy and Neurobiology (Course Director)
A - 404 - Research Elective (Course Director)
ResearchMy research interests concentrate in three areas: (1) anatomy and visualization of the white matter, (2) neural circuits implicated in neuropsychiatric illnesses, (3) mechanisms of action and optimization of brain stimulation techniques for therapeutic neuromodulation.
Dr. Segal’s research website
PublicationsSegal, S. Endoscopic Anatomy of the Ventricular System. (Chapter) In: King, W.A., Frazee, J.G., De Salles, A.: Endoscopy of the Central and Peripheral System. George Thieme Verlag, New York, 1997.
Segal, S. Endoscopic Surgical Anatomy. (Chapter) In: Jimenez, D.: Intracranial Endoscopic Neurosurgery. AANS Publications, Chicago, 1999.
Guppy K.H., Origitano T.C., Segal S., Reichman O.H. Venous Drainage of the Inferior-Lateral Temporal Lobe in Relationship to Transtemporal/Transtentorial Approaches to the Skull Base. Neurosurgery 41: 615 - 620, 1997.
De Leon MJ, Segal S, Tarshish CY, DeSanti S, Zinkowski R, Mehta PD, Convit A, Caraos C, Rusinek H, Tsui W, Saint Louis LA, DeBernardis J, Kerkman D, Qadri F, Gary A, Lesbre P, Wisniewski T, Poirier J, Davies P. Longitudinal cerebrospinal fluid tau load increases in mild cognitive impairment. Neurosci Lett. 2002 Nov 29; 333(3):183-6
Shrivastava RK, Segal S, Cammins MB, Sen C, Post KD. Harvey Cushing's Meningiomas text and the historical origin of respectability criteria for the anterior one third of the superior sagittal sinus. J Neurosurg. 2003 Oct; 99(4):787-91
De Leon MJ, DeSanti S, Zinkowski R, Mehta PD, Pratico D, Segal S, Clark C, Kerkman D, DeBernardis J, Li J, Lair L, Reisberg B, Tsui W, Rusinek H. MRI and CSF studies in the early diagnosis of Alzheimer's disease. J Intern Med. 2004 Sep; 256(3):205-23.
Rusinek H, Endo Y, DeSanti S, Frid D, Tsui WH, Segal S, Convit A, de Leon MJ. Atrophy rate in medial temporal lobe during progression of Alzheimer's disease. Neurology. 2004 Dec 28; 63(12):2354-9.
Golier JA, Yehuda R, De Santi S, Segal S, Dolan S, de Leon MJ. Absence of Hippocampal volume differences in survivors of the Nazi Holocaust with and without Post-traumatic stress disorder. Psychiatric Res 2005 May 30, 139(1):53-64
Li Y, Li J, Segal S, Wegiel J, De Santi S, Zhan J, de Leon MJ. Hippocampal cerebrospinal fluid spaces on MR imaging: Relationship to aging and Alzheimer's disease. Am J Neuroradiol. 2006 Apr;27(4):912-8 de Leon MJ, DeSanti S, Zinkowski R, Mehta PD, Pratico D, Segal S, Rusinek H, Li J, Tsui W, Saint Louis LA, Clark CM, Tarshish C, Li Y, Lair L, Javier E, Rich K, Lesbre P, Mosconi L, Reisberg B, Sadowski M, DeBernardis JF, Kerman DJ, Hampel H, Wahlund LO, Davies P. Longitudinal CSF and MRI biomarkers improve the diagnosis of mild cognitive impairment. Neurobiol Aging. 2006 Mar;27(3):394-401
Devanand DP, Pradhaban G, Liu X, Khandji A, De Santi S, Segal S, Rusinek H, Pelton GH, Honig LS, Mayeux R, Stern Y, Tabert MH, de Leon MJ. Hippocampal and entorhinal atrophy in mild cognitive impairment: prediction of Alzheimer disease. Neurology. 2007 Mar 13;68(11):828-36.
Mikell CB, McKhann GM, Segal S, McGovern RA, Wallenstein MB, Moore H. The hippocampus and nucleus accumbens as potential therapeutic targets for neurosurgical intervention in schizophrenia.
Stereotact Funct Neurosurg. 2009;87(4):256-65. Epub 2009 Jun 26. Review.