Enrico Di Cera, M.D., Alice A. Doisy Professor and Chairman of the department of biochemistry and molecular biology at Saint Louis University, will present "Engineering Thrombin for Anticoagulant Activity In Vivo" during Topics in Pathology at noon Monday, Jan. 31, in the Pitlyk Auditorium C, Learning Resources Center.
|Enrico Di Cera, M.D.|
|X-ray crystal structure of thrombin (surface) in complex with the uncleaved extracellular fragment of PAR1 (stick), the major receptor for platelet activation by thrombin. The 2Fo-Fc electron density map (light green mesh) for the uncleaved PAR1 fragment is contoured at 0.9 sigma. Residues of thrombin interacting with PAR1 through molecular contacts within 4 Å are colored in orange (hydrophobic contacts) or marine (polar contacts).|