Department of Biology
Dr. Claudio Casola
Assistant Professor - Ph.D., University of Pisa, Italy
Phone: (314) 977-3909
Fax: (314) 977-3658
Mail: Department of Biology, St. Louis University, 3507 Laclede Ave. St. Louis, MO 63103-2010
Courses: Genetics, Genome Biology
Research interests: The primary goal of my research is to understand the evolution of genome variation among species and populations. I use a combination of computational and statistical approaches to analyze whole-genome data sets from a variety of organisms, including both model and non-model species. I am mainly interested in studying the genome-wide consequences of illegitimate recombination, in particular gene duplication and gene loss through unequal crossing-over, and gene conversion. My work aims at understanding the role of these processes both in genome evolution and the onset of genetic disorders in human. Additional research interests in my lab include the origin of new genes and regulatory sequences from transposable elements (mobile genes), the evolution of genes involved in recombination, and the genome-wide impact of gene duplication through retrotransposition.
Research opportunities: Undergraduate and graduate students interested in evolutionary genomics/genetics, bioinformatics, and the genomic bases of human disease and evolution are encouraged to contact me for research opportunities. Programming skills are welcome but not required to work in the lab.
Casola C, Conant GC, Hahn MW "Very low rate of gene conversion in the yeast genome". Mol Biol Evol 2012 Jul 27. [Epub ahead of print]
Casola C, Zekonyte U, Phillips AD, Cooper DN, Hahn MW (2012) "Interlocus gene conversion events introduce deleterious mutations into at least 1% of human genes associated with inherited disease". Genome Res 22:429-35.
Emera D, Casola C, Lynch VJ, Wildman D, Agnew D, Wagner GP (2012) "Independent origin of alternative promoters for uterine PRL expression in the human and elephant lineage: the role of lineage specific transposable elements". Mol Biol Evol 29:239-47.
Colbourne JK, 66 more authors [Casola C, contributing author] (2011) "The expansive genome of Daphnia pulex with environment-dependent gene regulation". Science 331:555-61.
Locke DP, 104 more authors [Casola C, contributing author] (2011) "Comparative and demographic analysis of orangutan genomes". Nature 469:529-533.
Casola C, Ganote CL, Hahn MW (2010) "Non-allelic gene conversion in the genus Drosophila". Genetics 185:95-103.
Casola C, Hahn MW (2009) "Gene conversion among paralogs results in moderate false detection of positive selection using likelihood methods". J Mol Evol 68:679-87.
Han MV, Demuth JP, McGrath CL, Casola C, Hahn MW (2009) "Adaptive evolution of young gene duplicates in mammals". Genome Res 19:859-67.
McGrath CL, Casola C, Hahn MW (2009) "Minimal effect of ectopic gene conversion in four mammalian genomes". Genetics 182:615-22.
Casola C, Hucks D, Feschotte C (2008) "Convergent domestication of pogo-like transposases into centromere-binding proteins in fission yeast and mammals". Mol Biol Evol 25:29-41.
Lin R, Ding L, Casola C, Ripoll DR, Feschotte C, Wang H (2007) "Transposase-derived transcription factors regulate light signaling in Arabidopsis". Science 318:1302-5.
Casola C, Lawing AM, Betrán E, Feschotte C (2007) "PIF-like transposons are common in Drosophila and have been repeatedly domesticated to generate new host genes". Mol Biol Evol 24:1872-88.
Bai Y, Casola C, Feschotte C and Betrán E (2007) "Constant rate of origination and convergent acquisition of functional retrogenes in Drosophila". Genome Biol 8:R11.Updated 10/31/2012