Dale Dorsett, Ph.D.
Professor
Biochemistry and Molecular Biology
Research
Chromosome structure control of gene expression during development using
Research Interests
We use Drosophila molecular genetics to understand how chromosome structure controls gene expression during development. Our studies have shed light on the molecular mechanisms of Cornelia de Lange syndrome, which causes diverse developmental deficits in humans.
Publications
Recent
Cornelia de Lange syndrome and molecular implications of the cohesin complex: Abstracts
from the 7th biennial scientific and educational symposium 2016
Kline AD, Krantz ID, Deardorff MA, Shirahige K, Dorsett D, Gerton JL, Wu M, Mehta
D, Mills JA, Carrico CS, Noon S, Herrera PS, Horsfield JA, Bettale C, Morgan J, Huisman
SA, Moss J, McCleery J, Grados M, Hansen BD, Srivastava S, Taylor-Snell E, Kerr LM,
Katz O, Calof AL, Musio A, Egense A and Haaland RE
Pubmed | Am. J. Med. Genet. A
Measuring Sister Chromatid Cohesion Protein Genome Occupancy in Drosophila melanogaster
by ChIP-seq
Dorsett D and Misulovin Z
Pubmed | Methods Mol. Biol.
Drosophila TDP-43 RNA-Binding Protein Facilitates Association of Sister Chromatid
Cohesion Proteins with Genes, Enhancers and Polycomb Response Elements
Swain A, Misulovin Z, Pherson M, Gause M, Mihindukulasuriya K, Rickels RA, Shilatifard
A and Dorsett D
Pubmed | PLoS Genet.
Vitamin D receptor signaling improves Hutchinson-Gilford progeria syndrome cellular
phenotypes
Kreienkamp R, Croke M, Neumann MA, Bedia-Diaz G, Graziano S, Dusso A, Dorsett D, Carlberg
C and Gonzalo S
Pubmed | Oncotarget
The Drosophila melanogaster model for Cornelia de Lange syndrome: Implications for
etiology and therapeutics
Dorsett D
Pubmed | Am J Med Genet C Semin Med Genet