Huazhang Guo, M.D., Ph.D.
Assistant Professor
Pathology
Anatomical Pathology
Education
M.D., Fourth Military Medical University, China, 1996
Certifications
Molecular Genetic Pathology (2015)
Anatomical/Clinical Pathology (2014)
Missouri Medical License (2017--active)
Pennsylvania Medical License (2015--active)
Research Interests
Developing a common platform for molecular LDT tests, automation of molecular test reporting, customizing and interfacing lab information systems.
Publications
Guo H, Ray RM, Johnson LR. RhoA stimulates IEC-6 cell proliferation by increasing polyaminedependent Cdk2 activity. Am J Physiol Gastrointest Liver Physiol. 2003 Oct;285(4):G704-13. Epub 2003 Jun 19. PubMed PMID: 12816757.
Guo HZ, Yin Y, Wang WL, Zhang CS, Wang T, Wang Z, Zhang J, Cheng H, Wang HT. Sequence evolution of putative cytotoxic T cell epitopes in NS3 region of hepatitis C virus. World J Gastroenterol. 2004 Mar 15;10(6):847-51. PubMed PMID: 15040030.
Wang Z, Li Q, Huang GS, Liu SJ, Guo HZ, Zhang J, Cheng H, Xu J, Barenboim-Stapleton L, Ried T. Clinical report of congenital lymphatic malformations and partial gigantism of the hands associated with a heterogeneous karyotype. Am J Med Genet A. 2005 Jan 1;132A(1):106-7. PubMed PMID: 15472995.
Ray RM, Guo H, Patel M, Jin S, Bhattacharya S, Johnson LR. Role of myosin regulatory light chain and Rac1 in the migration of polyamine-depleted intestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol. 2007 Apr;292(4):G983-95. Epub 2006 Dec 14. PubMed PMID: 17170026.
Bhattacharya S, Guo H, Ray RM, Johnson LR. Basic helix-loop-helix protein E47-mediated p21Waf1/Cip1 gene expression regulates apoptosis of intestinal epithelial cells. Biochem J. 2007 Oct 15;407(2):243-54. PubMed PMID: 17617061.
Khurana S, Tomar A, George SP, Wang Y, Siddiqui MR, Guo H, Tigyi G, Mathew S. Autotaxin and lysophosphatidic acid stimulate intestinal cell motility by redistribution of the actin modifying protein villin to the developing lamellipodia. Exp Cell Res. 2008 Feb 1;314(3):530-42. Epub 2007 Nov 12. PubMed PMID: 18054784.
Guo H, Makarova N, Cheng Y, E S, Ji RR, Zhang C, Farrar P, Tigyi G. The early-and late stages in phenotypic modulation of vascular smooth muscle cells:differential roles for lysophosphatidic acid. Biochim Biophys Acta. 2008 Sep;1781(9):571-81. doi: 10.1016/j.bbalip.2008.06.003. Epub 2008 Jun 13. PubMed PMID: 18602022.
Khandoga AL, Fujiwara Y, Goyal P, Pandey D, Tsukahara R, Bolen A, Guo H, Wilke N, Liu J, Valentine WJ, Durgam GG, Miller DD, Jiang G, Prestwich GD, Tigyi G, Siess W. Lysophosphatidic acid-induced platelet shape change revealed through LPA(1-5) receptor-selective probes and albumin. Platelets. 2008 Sep;19(6):415-27. doi: 10.1080/09537100802220468. PubMed PMID: 18925509.
E S, Lai YJ, Tsukahara R, Chen CS, Fujiwara Y, Yue J, Yu JH, Guo H, Kihara A, Tigyi G, Lin FT. Lysophosphatidic acid 2 receptor-mediated supramolecular complex formation regulates its antiapoptotic effect. J Biol Chem. 2009 May 22;284(21):14558-71. doi: 10.1074/jbc.M900185200. Epub 2009 Mar 17. PubMed PMID: 19293149.
Cheng Y, Makarova N, Tsukahara R, Guo H, Shuyu E, Farrar P, Balazs L, Zhang C, Tigyi G. Lysophosphatidic acid-induced arterial wall remodeling: requirement of PPARgamma but not LPA1 or LPA2 GPCR. Cell Signal. 2009 Dec;21(12):1874-84. doi: 10.1016/j.cellsig.2009.08.003. Epub 2009 Aug 23. PubMed PMID: 19709640.
Professional Organizations and Associations
College of American Pathologists
Association for Pathology Informatics