Emergency Medicine Studies
Comparison of the RightSpot pH Indicator and RightLevel pH Detector the Gold Standard of Radiographic Verification of Feeding Tube Placement and Gastrostomy Tube Replacement
Study Sponsor: Right BIOMETRICS Fluid Technologies
Purpose: The purpose of this study is to see if use of the RightSpot pH Indicator and/or EZ-pH Indicator is as accurate in determining correct placement of feeding tubes and G-tube tubes as compared to the standard of care, which is getting an X-ray.
Principal Investigator: Timothy Havens, M.D.
Status: Active, Recruiting
Contact: Kathryn Lindsay, M.Ed., R.N., CCRN-K, CEN, CCRC, 314-577-8460 or lindsayk@slu.edu
General Surgery/Surgical Oncology Studies
A Multi-Center Study for the Collection of Surplus Surgical Tissues for Genomics, Proteomics and Biomarker Research (Fresh, Preserved, Blood)
Study Sponsor: Asterand US Acquisition Corp.
Purpose: The purpose of this study is to collect high-quality tissue samples and associated clinical data from consented study subjects.
Principal Investigator: Eddy Hsueh, M.D., FACS
Status: Active, Recruiting
Contact: Kathryn Lindsay, M.Ed., R.N., CCRN-K, CEN, CCRC, 314-577-8460, or lindsayk@slu.edu
An ongoing, five-year post market study to track clinical application, of DecisionDx-Melanoma Gene expression profile (GEP) Assay results and the impact on patient outcomes and health economics
Study Sponsor: Castle Biosciences, Inc.
Purpose: This study is being done to to collect information about how physicians are using the DecisionDx-CM results to design individual treatment plans. It will also track outcomes of the cutaneous melanoma patients that receive DecisionDx-CM testing.
Principal Investigator: Eddy Hsueh, M.D., FACS
Status: Active, Recruiting
Contact: Craig Dedert, B.S.N., R.N., CCRC, 314-577-8461
A Multicenter, Double-Blind, Placebo-Controlled, Adaptive Phase 3 Trial of POL-103A Polyvalent Melanoma Vaccine in Post-Resection Melanoma Patients with a High Risk of Recurrence
Study Sponsor: Polynoma, LLC
Purpose: The overall purpose of this research is to help determine how safe the investigational vaccine POL-103A is and how it works in humans who have melanoma.
Principal Investigator: Eddy Hsueh, M.D., FACS
Status: Active, Recruiting
Contact: Kathryn Lindsay, M.Ed., R.N., CCRN-K, CEN, CCRC, 314-577-8460, or lindsayk@slu.edu
A Registry Study to Evaluate the Survival and Long-Term Safety of Subjects With Melanoma Who Previously Received Talimogene Laherparepvec
Study Sponsor: Amgen Inc.
Purpose: The purpose of this observational registry study is to collect safety (i.e., whether people have side effects or not) and survival (i.e., whether people are alive or not) information on people who have previously received talimogene laherparepvec (formerly known as OncoVEXGM-CSF) in an Amgen or BioVex-sponsored clinical trial for the treatment of their melanoma cancer.
Principal Investigator: Eddy Hsueh, M.D., FACS
Status: Active, Enrolling by invitation only
Contact: Kathryn Lindsay, M.Ed., R.N., CCRN-K, CEN, CCRC, 314-577-8460 or linedudsayk@slu.
Phase 1b/2, Multicenter, Open-label Trial to Evaluate the Safety and Efficacy of Talimogene Laherparepvec and Ipilimumab Compared to Ipilimumab Alone in Subjects With Unresected, Stage IIIB-IV Melanoma
Study Sponsor: Amgen Inc.
Purpose: The purpose of this study is to find out more about talimogene laherparepvec (formerly known as OncoVEXGM-CSF), in people with advanced melanoma when given in combination with another drug called ipilimumab.
Principal Investigator: Eddy Hsueh, M.D., FACS
Status: Active, Recruiting
Contact: Kathryn Lindsay, M.Ed., R.N., CCRN-K, CEN, CCRC, 314-577-8460 or lindsayk@slu.edu
Randomized Trial of Sentinel Lymphadenectomy and Complete Lymph Node Dissection versus Sentinel Multicenter Selective Lymphadenectomy for Melanoma Trial II: A Phase III Multicenter Lymphadenectomy Alone in Cutaneous Melanoma Patients with Molecular or Histopathological Evidence of Metastases in the Sentinel Node
Study Sponsor: John Wayne Cancer Institute
Purpose: The overall purpose of the research is to find out if melanoma can be treated by removing only a few lymph nodes (called “sentinel nodes”) from a lymph node basin (called a “sentinel node dissection”), or if all lymph nodes in a lymph basin must be removed (called a “complete lymph node dissection”).
Principal Investigator: Eddy Hsueh, MD, FACS
Status: Active, Closed to Recruitment
Contact: Pam Hunborg, B.S.N., R.N., CCRC, 314-268-5409 or hunborgp@slu.edu
Vascular Surgery Studies
Evaluation of the GORE Conformable TAG® Thoracic Endoprosthesis for Treatment of Traumatic Transection of the Descending Thoracic Aorta
Study Sponsor: W. L. Gore & Associates Inc.
Purpose: The overall purpose of this research is to determine the safety and efficacy of the GORE Conformable TAG® ThoracicEndoprosthesis for Treatment of Traumatic Transection of the Descending Thoracic Aorta (the “study device”) as minimally invasive treatment alternative for traumatic aortic transection patients.
Principal Investigator: Brian Peterson, M.D., FACS
Status: Active, Closed to recruitment
Contact: Craig Dedert, B.S.N., R.N., CCRC, (314) 577-8461
A Randomized, Double-Blind, Parallel Group, Multicentre Phase IIIb Study to Compare Ticagrelor With Clopidogrel Treatment on the Risk of Cardiovascular Death, Myocardial Infarction and Ischemic Stroke in Patients With Established Peripheral Artery Disease (EUCLID Examining Use of tiCagreLor In paD)
Study Sponsor: AstraZeneca
Purpose: The overall purpose of this research is to test the hypothesis that ticagrelor monotherapy when compared with clopidogrel monotherapy will reduce the incidence of atherothrombotic ischemic events, as measured by the composite of CV death, MI, and ischemic stroke in patients with established PAD.
Principal Investigator: Catherine Wittgen, M.D., FACS
Status: Active, Closed to recruitment
Contact: Kathryn Lindsay, M.Ed., R.N., CCRN-K, CEN, CCRC, 314-577-8460 or lindsayk@slu.edu
LEOPARD Study: A Multicenter, Prospective, Randomized, Post-Market, Real-World Study to Assess Outcomes of Patients Treated with the AFX® System Compared to other EVAR Devices for Endovascular Abdominal Aortic Aneurysm Repair
Study Sponsor: Endologix Inc.
Purpose: Objective of this post-market study is to evaluate Endologix AFX endovascular AAA system with anatomical fixation against other approved Endovascular systems with proximal fixation.
Principal Investigator: Emad Zakhary, M.D.
Status: Active, Open to recruitment
Contact: Craig Dedert, B.S.N., R.N., CCRC, 314-577-8461
Delivery of Dexamethasone to the Adventitia to Enhance Clinical Efficacy after Femoropopliteal Revascularization (DANCE)
Study Sponsor: Mercator Medsystems Inc.
Purpose: To assess the safety and effectiveness of adventitial deposition of the Study Drug in reducing inflammation and restenosis in patients with clinical evidence of claudication or critical limb ischemia and an angiographically significant lesion in the superficial femoral and/or popliteal arteries.
Principal Investigator: Donald Jacobs, MD
Status: Active, Recruiting
Contact: Craig Dedert, B.S.N., R.N., CCRC, 314-577-8461