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15-024 Antibodies recognizing phoshorylation at TDP-43

Researchers

Yuna Alaya

Summary

This invention relates to the production of antibodies to recognize phosphorylation at specific TDP-43 amino acid residues. These antibodies can be used as a diagnostic tool for TDP-43-associated neurodegenerative disorders including amyotrophic lateral sclerosis (ALS), frontotemporal lobar degeneration, Alzheimer’s disease, inclusion body myositis, inclusion body myopathy associated with Paget’s disease of the bone and fronto-temporal dementia (IBMPFD, OMIM 167320), limb-girdle muscular dystrophy (LGMD), neuronal injury and chronic traumatic encephalopathy.

Intellectual Property Status

  • U.S. patent pending