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15-015 - MCPIP1 tumor suppressor

Researchers

Jianguo Liu, Wenbao Lu and Huan Ning.

Summary

This invention includes an isolated polynucleotide, monocyte chemotactic protein induced protein 1 (MCPIP1), that is a potent tumor suppressor that induces apoptosis of breast tumor cells by selectively enhancing mRNA decay of anti-apoptotic gene transcripts, including Bcl2L1, Bcl2A1, RelB, Birc3, and Bcl3.  MCPIP1 expression is repressed in breast tumor cells.  MCPIP1 induction in vivo completely abrogates established tumors and significantly reduced metastasis.

Intellectual Property Status

  • U.S. patent pending