16-001.1 - Inhibition of Cryptococcus Neoformans by antagonists of the nucleotide transferase superfamily

Researchers

Maureen J. Donlin, John E. Tavis, Ryan P. Murelli and Marvin Meyers.

Summary

Saint Louis University researchers have discovered several different compound classes with inhibitory activity against enzymes in the nucleotidyl transferase superfamily. These include α–hydroxytropolones, hydroxychromenones, HIDs, as well as two approved drugs for skin-associated fungi, ciclopirox olamine and piroctone olamine. The invention includes therapeutic combination of these inhibitors which may lead to treatments for fungal infections, such as infections of Cryptococcus neoformans, which are a growing problem for people who are immunocompromised.  There remains a need to develop new therapeutic options for these diseases. 

Reference SLU disclosure 16-001.

Intellectual Property Status

• U.S. patent pending